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FERULIC ACID METHYL ESTER

CAS No. 2309-07-1

FERULIC ACID METHYL ESTER ( Methyl ferulate )

产品货号. M17722 CAS No. 2309-07-1

阿魏酸是一种羟基肉桂酸,富含于植物中,最初源自大茴香 (F. commis)。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
100MG ¥332 有现货
200MG ¥470 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    FERULIC ACID METHYL ESTER
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    阿魏酸是一种羟基肉桂酸,富含于植物中,最初源自大茴香 (F. commis)。
  • 产品描述
    Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer. Ferulic acid methyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes.(In Vitro):Ferulic acid methyl ester (25 μg/mL) has no cytotoxic effects on BMDMs after treatment for 6 h, 18 h, 48 h.Ferulic acid methyl ester (Methyl ferulate; 5, 10, 25 μg/mL) suppresses TNFα, IL6, IFNγ but not IL10, inhibits NO generation at 10 and 25 μg/mL, in primary bone marrow derived-macrophages (BMDMs).Ferulic acid methyl ester (25 μg/mL) inhibits COX-2 expression, blocks p-p38 and p-JNK.
  • 体外实验
    Ferulic acid methyl ester (25 μg/mL) has no cytotoxic effects on BMDMs after treatment for 6 h, 18 h, 48 h.Ferulic acid methyl ester (Methyl ferulate; 5, 10, 25 μg/mL) suppresses TNFα, IL6, IFNγ but not IL10, inhibits NO generation at 10 and 25 μg/mL, in primary bone marrow derived-macrophages (BMDMs).Ferulic acid methyl ester (25 μg/mL) inhibits COX-2 expression, blocks p-p38 and p-JNK. Cell Viability Assay Cell Line:Primary bone marrow derived-macrophages (BMDMs)C oncentration:25 μg/mL Incubation Time:6 h, 18 h, 48 hResult:Showed no cytotoxic effects on BMDMs.Western Blot Analysis Cell Line:RAW 246.7 cells Concentration:10 μg/mL and 25 μg/mL Incubation Time:For 1 h before stimulation with LPS Result:Significantly suppressed COX-2 expression at 25 μg/mL.
  • 体内实验
    ——
  • 同义词
    Methyl ferulate
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    2309-07-1
  • 分子量
    208.21
  • 分子式
    C11H12O4
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : ≥ 100 mg/mL480.28 mM; H2O : 2 mg/mL9.61 mM;
  • SMILES
    Oc1ccc(cc1OC)/C=C/C(=O)OC
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Huang M T, etal. Cancer Research, 1988, 48(21):5941-5946.
产品手册
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